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pentobarbital will decrease the level or result of cobimetinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Prevent coadministration. Powerful or moderate CYP3A inducers may lessen cobimetinib systemic exposure by >eighty% and lessen its efficacy.pentobarbital will decrease the level or impact of bazedoxifene/conjugate